Tri Mix

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This is a general recommendation for the administration of Bi-Mix, Tri-Mix or Quad Mix. All patients should review the proper administration techniques with their physician prior to administration of any injectable therapy.

Getting Started

  • Wash hands and keep the penis clean.
  • Have alcohol swab, syringe, and bottle of injectable solution ready.

The Syringe

  • Wipe the rubber top of the vial containing tri-mix with alcohol.
  • Remove the cap of the needle, fill the syringe with air by pulling back the plunger to the desired dosage.
  • Insert the needle into the rubber stop of the vial, inject the air, and then turn the vial upside down with the needle inside.
  • Slowly Pull back the syringe to the dosage required.
  • Tap the side of the syringe so the air bubbles float to the top and inject out the air bubbles before use.
  • Remove the needle from the bottle and recap.

Prepare The Site

  • Location of injection is between the base and mid portion of the penis at 9-11 and 1-3 o’clock. Avoid the midline because it can injure the urethra (where urine and sperm pass) and the penile arteries and nerves at 12 o’clock. Avoid any visible veins or arteries on the surface.
  • Pull the head of the penis towards to side of the leg and select a site for injection.
  • Clean the site with alcohol.


  • Steadily penetrate the skin with the needle at 90º. Push the needle to the end.
  • Inject Trimix over a few seconds and withdraw the needle.
  • Apply compression at the injection site for 2 minutes. More time may be needed to prevent bleeding.
  • Dispose the needle and syringe in the proper container.

General Rules For Injection

  • Use the smallest effective dose. Further dosage increases may result in more adverse effects.
  • Injections should be given at a maximum of three times per week or once every 2 days.
  • Seek medical attention if an erection lasts longer than 4 hours.
  • Sexual stimulation should occur after injection.

Common Causes of Inadequate Response

  • Injection into wrong location
  • Leakage of agent prior to injection
  • Premature Ejaculation during stimulation
  • Feelings of stress prior, during or after injection
  • Localized pain during and after the injection process
  • Inadequate Dose

Steps To Correct Inadequate Response

  • Review injection technique
  • Review injection technique
  • Evaluate timing of injection in relation to stimulation
  • Involve partner and inject in a comfortable environment
  • Try combination therapy with lower PGE-1 dose
  • Reassess dose with your physician and if approved by physician increase in 2-3 days or change to a more potent agent it at maximum doses



The information on this website if purely informational and should not be used to diagnose, cure or treat any patient without the direction and supervision of a physician. If you are intersted in using Tri-Mix or any other treatment for erectile dysfunction make sure to check with your physician first. This and any therapy should be individualized for you by a prescribing physician that knows you, your medical history, and any current and prior medication history. Tri-Mix is not approved by the FDA for the treatment of Erectile Dysfunction and does require a prescription that can only be filled at a compounding pharmacy.

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